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Search for "artificial receptors" in Full Text gives 12 result(s) in Beilstein Journal of Organic Chemistry.
Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups
Beilstein J. Org. Chem. 2022, 18, 1322–1331, doi:10.3762/bjoc.18.137
- to efficiently bind to oxo-anions such as carboxylates [10]. These compounds were already used to specifically address carboxylates on the surface of proteins. Many artificial receptors based on guanidinium scaffolds use hydrogen bonding, charge pairing, and hydrophobic interactions to complex oxo
Chiral anion recognition using calix[4]arene-based ureido receptors in a 1,3-alternate conformation
Beilstein J. Org. Chem. 2020, 16, 2999–3007, doi:10.3762/bjoc.16.249
- have gradually been revealed and are well recognised to date. Consequently, given the importance of anions in many areas of everyday life, including, e.g., biology, medicine, environmental pollution issues, or industrial processes, the design and development of novel artificial receptors/sensors for
Encrypting messages with artificial bacterial receptors
Beilstein J. Org. Chem. 2020, 16, 2749–2756, doi:10.3762/bjoc.16.225
- receptors is described. We show that the binding of DNA-based artificial receptors to E. coli expressing His-tagged outer membrane protein C (His-OmpC) induces a Förster resonance energy transfer (FRET) between the dyes, which results in the generation of a unique fluorescence fingerprint. Because the
- information protection at the molecular level. Keywords: artificial receptors; cell surface modification; fluorescent probes; molecular cryptography; Introduction In living cells, information is processed and transferred via a series of recognition and signaling events, which normally begin by the binding
- of cell-surface receptors to extracellular signals, such as small molecules or proteins. In recent years, there has been considerable interest in modifying cells with artificial receptors, as a means to provide them with new properties [1]. We have recently reported a method for decorating His-tagged
A dynamic combinatorial library for biomimetic recognition of dipeptides in water
Beilstein J. Org. Chem. 2020, 16, 1588–1595, doi:10.3762/bjoc.16.131
- motifs were developed and if arranged correctly can be used to synthesize artificial receptors with high affinity [2][3]. Schmuck et al. have been hugely successful in designing artificial peptide receptors [4][5]. For example, they combined a carboxylate binding site with an aromatic bowl-shaped cavity
- . A more general approach for the development of artificial receptors can be the use of a dynamic combinatorial library (DCL). In a DCL a large variety of molecules is generated by a dynamic exchange of building blocks. The dynamic nature of those exchange reactions is essential since it allows the
- library to be under thermodynamic control. Therefore, the equilibrium responds to stimuli such as addition of a template, which would stabilize a suitable receptor and thus amplifies its formation. This strategy has led to the discovery of many artificial receptors [7][8][9][10], with thiolate disulfide
Complexation of a guanidinium-modified calixarene with diverse dyes and investigation of the corresponding photophysical response
Beilstein J. Org. Chem. 2019, 15, 1394–1406, doi:10.3762/bjoc.15.139
- binding of the analyte gives rise to an extraordinary luminescence response of the reporter dye. Macrocyclic hosts constitute a family of well-studied artificial receptors with a discrete cavity that is selective for complementary binding to certain guests [9]. Modulation of properties of organic
- time, directed by exploring biomedical applications of these compounds. Recently, we developed a series of guanidinium-modified calixarenes as novel artificial receptors [13][14]. We achieved ultrasensitive and specific fluorescence detection of lysophosphatidic acid (a cancer biomarker) by executing
- luminescent materials, high-performance supramolecular dye lasers, and dye-sensitized solar cells. Although in our present study GC5A has served as a specific test case for molecular recognition of various dyes, such an investigation is inspirable for other artificial receptors, especially those of new
Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene
Beilstein J. Org. Chem. 2018, 14, 1840–1845, doi:10.3762/bjoc.14.157
- particularly suitable for the detection of analytes lacking chromophores. The key factor in IDA is the rational design of artificial receptors that are capable of binding analytes strongly and specifically. Calixarenes are the third generation of macrocyclic receptors after crown ethers and cyclodextrins. Due
Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system
Beilstein J. Org. Chem. 2012, 8, 539–550, doi:10.3762/bjoc.8.62
- intrinsic properties of these monomers on a molecular level [49]. First of all I, III, and IV were employed as artificial receptors characterized by more flexible lateral chains. The effect of the skeleton rigidity was evaluated by further investigation of the kinetic behavior of the rigid V and VI resorcin
pH-Responsive chromogenic-sensing molecule based on bis(indolyl)methene for the highly selective recognition of aspartate and glutamate
Beilstein J. Org. Chem. 2011, 7, 218–221, doi:10.3762/bjoc.7.29
- )methene; colorimetric sensor; molecular recognition; proton transfer; Introduction The development of artificial receptors for the selective recognition of biologically important species has attracted much attention [1][2]. However, compared to the large number of chromo/fluororeceptors for cations or
- anions [3][4][5][6][7], the development of artificial receptors for amino acids is quite limited. The effective and selective molecular recognition or sensing of unprotected amino acids in aqueous solution is still a challenging problem due to their highly hydrophilic character [8]. Several studies have
A new fluorescent chemosensor for fluoride anion based on a pyrrole–isoxazole derivative
Beilstein J. Org. Chem. 2011, 7, 46–52, doi:10.3762/bjoc.7.8
- is brought about by deprotonation of the pyrrole-NH in receptor 1. Keywords: deprotonation; fluorescent chemosensor; fluoride anion recognition; Introduction The development of anion receptors has become a field of substantial interest and activity [1][2][3]. Among the various artificial receptors
Anthracene appended pyridinium amide–urea conjugate in selective fluorometric sensing of L-N-acetylvaline salt
Beilstein J. Org. Chem. 2010, 6, 1211–1218, doi:10.3762/bjoc.6.139
- ; pyridinium amide–urea conjugate; Introduction The design and synthesis of artificial receptors capable of recognizing α-hydroxy and N-acetyl-α-amino acid carboxylates (i.e., salts of α-amino acids) is an active area of interest in supramolecular chemistry due to the biological significance and practical
Molecular recognition of organic ammonium ions in solution using synthetic receptors
Beilstein J. Org. Chem. 2010, 6, No. 32, doi:10.3762/bjoc.6.32
- attempting to cover all available references. Representative molecules for application in ion selective electrodes (ISE) [96] are briefly discussed. Unfortunately, the scope of the review cannot cover the topic of artificial receptors for organic ammonium ions comprehensively. It is rather the intention to
Recognition properties of receptors consisting of imidazole and indole recognition units towards carbohydrates
Beilstein J. Org. Chem. 2010, 6, No. 9, doi:10.3762/bjoc.6.9
- formation of the CH···π interactions with the aromatic rings of the receptor (for discussions on the importance of carbohydrate–aromatic interactions, see refs. [57][58][59][60][61][62][63]; for examples of CH-π interactions in the crystal structures of the complexes formed between artificial receptors and
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